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August 4, 2008

Aleksander Solzhenitsyn, Hero of Freedom, RIP


I heard last night that Aleksander Solzhenitsyn had died late that on that day, August 3, 2008.

Like all of us, he had his flaws. But he had strong moral courage in standing up against the enslavement of the masses by the communist tyranny of the USSR. For that he paid a huge price, partly in the form of the years of forced labor in the prison camps that he carefully documented in his massive The Gulag Archipelago. (I must admit that I never read The Gulag, although I believe my father, to his credit, read every page.)

I remember my mentor Ben Rogge reading The First Circle and highly recommending it to us. The book's title is based on Dante's Inferno which describes the nine circles of hell, where each successive circle assigns increasingly horrendous eternal punishments, for those guilty of increasingly terrible sins. In the first circle, good people born before Jesus, are allowed to pursue their interests much as they had on earth. Socrates, Plato and Aristotle, for instance, engage in eternal dialogue.

In Solzhenitsyn's version, Stalin allows a group of scientists to have better living conditions, and somewhat more freedom than ordinary Soviet citizens, so long as the scientists make progress on projects that enable Stalin to extend his power.

One of the revelations in the book is that those who imposed the tyranny, had motives that were not always evil. One bureaucratic candidate for villainy, for instance, did bad things, in order to protect his family. At the top there is Stalin, but he is portrayed as insane.

The point is one that Rogge often made---people are pretty much the same everywhere. What mainly explains the differences in different societies are different institutions that provide differing incentives and constraints.

It is a fitting tribute to Solzhenitsyn that the first unabridged English translation of The First Circle will soon be published.

I salute Solzhenitsyn for his insights, and even more, for his courage at standing up against an evil system.

August 3, 2008

Sprouted "Methuselah" Seed Is 2,000 Years Old


MethuselahDatePalmSeedsAndPlant.jpg


"One of a handful of 2,000-year-old seeds (top) from the fortress of Masada in present-day Israel grew into a date palm plant (bottom) called Methuselah in 2005." Source of caption and photos: online article quoted and cited below.

The oldest-sprouted seed in the world is a 2,000-year-old plant from Jerusalem, a new study confirms.

"Methuselah," a 4-foot-tall (1.2-meter-tall) ancestor of the modern date palm, is being grown at a protected laboratory in the Israeli capital.

In 2005 the young plant was coaxed out of a seed recovered in 1963 from Masada, a fortress in present-day Israel where Jewish zealots killed themselves to avoid capture by the Romans in A.D. 70.



For the full story, see:


Anne Minard. ""Methuselah" Tree Grew From 2,000-Year-Old Seed." National Geographic News online (June 12, 2008), downloaded on 6/19/08 from: http://news.nationalgeographic.com/news/2008/06/080612-oldest-tree.html


April 25, 2008

Active Volcano in Antarctica: Another Cause for Melting Ice


VolcanoActiveAntarctic.jpg Source of graphic: online version of the NYT article quoted and cited below.

(p. A8) Here is another factor that might be contributing to the thinning of some of the Antarctica's glaciers: volcanoes.

In an article published Sunday on the Web site of the journal Nature Geoscience, Hugh F. J. Corr and David G. Vaughan of the British Antarctic Survey report the identification of a layer of volcanic ash and glass shards frozen within an ice sheet in western Antarctica.

For Antarctica, "This is the first time we have seen a volcano beneath the ice sheet punch a hole through the ice sheet," Dr. Vaughan said.

Heat from a volcano could still be melting ice and contributing to the thinning and speeding up of the Pine Island Glacier, which passes nearby, but Dr. Vaughan doubted that it could be affecting other glaciers in West Antarctica, which have also thinned in recent years. Most glaciologists, including Dr. Vaughan, say that warmer ocean water is the primary cause.


For the full story, see:

KENNETH CHANG. "Scientists Find Active Volcano In Antarctica." The New York Times (Mon., January 21, 2008): A8.

March 25, 2008

Government Post-Doc Funding Creates "Glut" of Scientists


The quotes below from a WSJ summary of a Nov. 16, 2007 The Chronicle of Higher Education article, suggests that we do not need to worry about the sometimes-alleged "shortage" of scientists and engineers:


(p. B14) The federal dollars pumped into university science departments has created more scientists and engineers than the market wants, said Michael S. Teitelbaum, vice president of Alfred P. Sloan Foundation, which sponsors research, at a hearing in Congress last week. Mr. Teitelbaum said the federal government should find a way to adjust how it funds university research so that university departments don't end up using the extra money to add graduate students and postdoctoral fellows

For the full summary, see:

"The Informed Reader; Science; U.S. Faces a Glut (Really) of Scientists, Engineers." The Wall Street Journal (Tues., November 13, 2007): B14.

March 21, 2008

"The Chronically Apalled Must Not Have the Last Word"


(p. A20) Unfortunately, the deniers of differences between the sexes are on the march with powerful allies. In the fall of 2006, the National Academy of Sciences released a recklessly one-sided study, now widely referred to as authoritative, titled "Beyond Bias and Barriers: Fulfilling the Potential of Women in Academic Science and Engineering." According to the report, differences in cognition between the sexes have no bearing on the dearth of women in academic math, physics and engineering. It is all due to bias. Case closed. The report calls on Congress to hold hearings on gender bias in the sciences and on federal agencies to "move immediately" (emphasis in original) to apply anti-discrimination laws such as Title IX to academic science (but not English) departments. "The time for action is now."

No it is not. Now is the time for scholars in our universities and in the National Academy of Sciences to defend and support principles of free and objective inquiry. The chronically appalled must not have the last word.


For the full commentary, see:

Christina Hoff Sommers. "Academic Inquisitors." Wall Street Journal (Tues., Oct. 16, 2007): A.20.

February 22, 2008

"Sometimes It Pays to Read the Old Literature"


(p. A1) Researchers in New York believe they have solved one of the great mysteries of the flu: Why does the infection spread primarily in the winter months?

The answer, they say, has to do with the virus itself. It is more stable and stays in the air longer when air is cold and dry, the exact conditions for much of the flu season.

. . .

(p. A22) To his surprise, Dr. Palese stumbled upon a solution that appeared to be a good second best.

Reading a paper published in 1919 in the Journal of the American Medical Association on the flu epidemic at Camp Cody in New Mexico, he came upon a key passage: "It is interesting to note that very soon after the epidemic of influenza reached this camp, our laboratory guinea pigs began to die." At first, the study's authors wrote, they thought the animals had died from food poisoning. But, they continued, "a necropsy on a dead pig revealed unmistakable signs of pneumonia."

Dr. Palese bought some guinea pigs and exposed them to the flu virus. Just as the paper suggested, they got the flu and spread it among themselves. So Dr. Palese and his colleagues began their experiments.

. . .

As for Dr. Palese, he was glad he spotted the journal article that mentioned guinea pigs.

"Sometimes it pays to read the old literature," he said.

 

For the full story, see:

GINA KOLATA. "Study Shows Why the Flu Likes Winter." The New York Times (Weds., December 5, 2007): A1 & A22.

(Note:  ellipses added.)

 

February 20, 2008

Government Biologists Spend Big Bucks Protecting Wrong Fish


CutthroatTrout.jpg

"Without DNA tests, the rare greenback cutthroat trout, left, and the Colorado River cutthroat fish are difficult to tell apart." Source of caption and photo: online version of the NYT article quoted and cited below.

 

(p. 26) DENVER, Oct. 13 (AP) -- State and federal biologists, who are smarting from research showing that they may have been protecting the wrong fish the past 20 years, are regrouping in their efforts to restore the rare greenback cutthroat trout to Colorado waters.

Tom Nesler, the state biologist, had hoped to see the fish removed from the endangered species list during his career. He concedes that might not happen if it turns out some of the greenback populations biologists thought they were saving are actually the similar but more common Colorado River cutthroat trout.

A three-year study led by University of Colorado researchers and published in August found that out of nine fish populations believed to be descendants of original greenbacks, five were actually Colorado River cutthroat trout.

The recovery effort was thought to be near its goal of establishing 20 self-sustaining greenback populations.

"Hey, science happens," said Mr. Nesler with a shrug as he discussed the findings.

. . .

The Colorado Division of Wildlife has spent an average of $320,000 annually for the past five years to restore the greenback. Most of the money has come from state lottery revenue; no state tax dollars have been used.

. . .

"Science is not about proof and certainty," he said, "it's about testable hypotheses."

 

For the full story, see:

THE ASSOCIATED PRESS. "After Possible 'Oops,' a Trout Rescue Project Regroups." The New York Times, First Section (Sun., October 14, 2007): 26.

(Note: ellipses added.)

 

February 15, 2008

Private Money Supports Quest for Dinosaur DNA

 

   Source of graphic: the online version of the WSJ article quoted and cited below.

 

(p. A1)  JORDAN, Mont. -- Prospecting in Montana's badlands, rock ax in hand, paleontologist Jack Horner picks up a piece of the jawbone of a dinosaur. He examines the splinter, then puts it back and moves on. It isn't the kind of bone he is looking for.

Prof. Horner is searching for something that many scientists believe no longer exists: dinosaur bones that harbor blood cells, protein and, perhaps, even DNA.

"Most people looking for dinosaurs are looking for beautiful skeletons," he says. "We are looking for information."

. . .  

Prof. Horner, a curator at the Museum of the Rockies in Bozeman, is among the world's most influential and offbeat paleontologists. He pioneered studies of dinosaur parent-(p. A12)ing behavior, species variation and bone cells. He is dyslexic, a former Special Forces operative of the Vietnam War era, a MacArthur Foundation "genius" fellow, and a chaired professor of Montana State University who never finished a formal college degree.

"The lenses that people normally use to look at stuff are broken in Jack," says Mary Schweitzer, an assistant professor of paleontology at North Carolina State University, who has worked with him for years. "That's what makes Jack such a good scientist. Every now and then, every field should get a renegade weirdo in it who challenges assumptions."

. . .  

"The chances of finding any [dinosaur] DNA are pretty low," Prof. Horner acknowledges. "I am still hopeful."

In a field mostly outside the mainstream of federal research funding, Prof. Horner has a knack for attracting private grants. Star Wars producer George Lucas, Qualcomm co-founder Klein Gilhousen and Wade Dokken, a developer of Montana real estate, have contributed toward his research, the university says. Nathan Myhrvold, formerly chief technology officer at Microsoft Corp. and co-founder of Intellectual Ventures LLC, is helping to underwrite this season's fieldwork.

This summer, in Montana's Hell Creek Formation, Prof. Horner is searching the last landscape inhabited by dinosaurs. More than 65 million years ago, this plain was a wetland where herds of horned Triceratops watered. Today, it is an arid outwash of boulders, cactus and sage. The red and gray soil is littered with white shards of petrified wood that ring like bone china when tapped together and countless crumbs of dinosaur bone.

. . .

"As long as you are not bound by preconceived ideas of what you can find," Prof. Horner says, "there are an awful lot of things you can discover."

 

For the full story, see:

ROBERT LEE HOTZ. "Dinosaur Hunter Seeks More Than Just Bare Bones; Prof. Horner Searches For Traces of Blood, DNA; Lucky Break From T. Rex."  The Wall Street Journal  (Fri., August 24, 2007):  A1 & A12.

(Note:  ellipses added.)

  

     At top, Prof. Horner; at bottom: "Sarah Keenan, 21, an undergraduate at the University of St. Andrews in Scotland who is working this summer for Prof. Horner, covers the fossilized triceratops frill in a protective jacket of plaster."  Source of caption and photos: the online version of the WSJ article quoted and cited above.

 

January 29, 2008

Marconi Matters

 

    Source of book image:  http://palmaddict.typepad.com/photos/uncategorized/big_larsonthunderstruckdrm_1.jpg

 

Larson's book plays off a murder mystery against Marconi as the innovator who brought us communication through the air. 

I'm most enthused about hte Marconi part.  It shows how he proceeded against the theorists of the day, whose theories told them that what he was trying to do was impossible.  He was more entrepreneur, than scientist.  And it turned out that it was a good thing that the theoretical scientists did not rule, as they might if all decisions about technology were made by the government.

What happened here is an example of what Taleb would call a Black Swan.

 

Source:

Larson, Erik. Thunderstruck. New York: Crown, 2006.

 

Marconi Matters

 

    Source of book image:  http://palmaddict.typepad.com/photos/uncategorized/big_larsonthunderstruckdrm_1.jpg

 

Larson's book plays off a murder mystery against Marconi as the innovator who brought us communication through the air. 

I'm most enthused about hte Marconi part.  It shows how he proceeded against the theorists of the day, whose theories told them that what he was trying to do was impossible.  He was more entrepreneur, than scientist.  And it turned out that it was a good thing that the theoretical scientists did not rule, as they might if all decisions about technology were made by the government.

What happened here is an example of what Taleb would call a Black Swan.

 

Source:

Larson, Erik. Thunderstruck. New York: Crown, 2006.

 

November 7, 2007

Entrepreneur Venter Advances Toward Useful Control of Cells

 

   Source of graphic:  online version of the NYT article quoted and cited below.

 

Scientists at the institute directed by J. Craig Venter, a pioneer in sequencing the human genome, are reporting that they have successfully transplanted the genome of one species of bacteria into another, an achievement they see as a major step toward creating synthetic forms of life.

Other scientists who did not participate in the research praised the achievement, published yesterday on the Web site of the journal Science. But some expressed skepticism that it was as significant as Dr. Venter said.

His goal is to make cells that might take carbon dioxide out of the atmosphere and produce methane, used as a feedstock for other fuels. Such an achievement might reduce dependency on fossil fuels and strike a blow at global warming.

“We look forward to having the first fuels from synthetic biology certainly within the decade and possibly in half that time,” he said.

Richard Ebright, a molecular biologist at Rutgers University, said the transplantation technique, which leads to the transferred genome’s taking over the host cell, was “a landmark accomplishment.”

“It represents the complete reprogramming of an organism using only a chemical entity,” Dr. Ebright said.

Leroy Hood, a pioneer of the closely related field of systems biology, said Dr. Venter’s report was “a really marvelous kind of technical feat” but just one of a long series of steps required before synthetic chromosomes could be put to use in living cells.

 

For the full story, see: 

NICHOLAS WADE. "Pursuing Synthetic Life, Scientists Transplant Genome of Bacteria."  The New York Times   (Fri., June 29, 2007):  A1 & A18.

 

VenterCraig.jpg   J. Craig Venter.  Source of photo:  online version of the NYT article quoted and cited above.

 

September 4, 2007

Astronauts (and the Rest of Us) Would Benefit from More Unscripted Time

 

Noctilucent clouds.  Source of photo:  http://apod.nasa.gov/apod/image/9907/noctilucent_pp.jpg

 

The excerpt below is from a WSJ summary of an article from the  June 2007 issue of Seed.

 

Many other scientific discoveries have come from astronauts puzzling over strange sights around them. Most of what is known about so-called noctilucent clouds -- thin, beautiful wisps that hover at the edge of the Earth's atmosphere -- comes from 30 years of astronauts sketching and trying to photograph them in their spare time. The strength of a certain type of cosmic ray was first recognized in 1969 when Buzz Aldrin asked fellow astronauts if they, like him, were seeing occasional streaks of light when their eyes were closed.

Such discoveries off the beaten path of the National Aeronautic and Space Administration's research agenda prompt the question attributed to an Apollo program geologist: "If human beings can do much better science than robots, why does NASA make its astronauts do science like robots?"

 

For the full summary, see: 

"Informed Reader; SCIENCE; Why Astronauts Need Down Time in Space."  The Wall Street Journal (Weds., May 9, 2007):  B15.

 

August 11, 2007

Easily Available Capital and Technology Lower Barriers to Entry in Oil Industry

 

CobaltOilDataAnalysis.jpg   "Cobalt scientists analyze data to help pinpoint oil deposits."  Source of caption and photo:  online version of the NYT article cited below.

 

(p. 1)  HOUSTON.  JOSEPH H. BRYANT, still boyish-looking at 51, jostles with glee among tens of thousands of people here at the Offshore Technology Conference, one of the energy industry’s biggest trade fairs. He is surrounded by newfangled technologies occupying more than half a million square feet of display space: drills stuffed with electronic sensors, underwater wells shaped like Christmas trees, mini-submarines and pipes, pumps, tubes, gauges, valves and gadgets galore.

“There is every little gizmo you need to make this business work,” Mr. Bryant says, joyously. He stops at a plastic model of an offshore oil rig, an exact replica of a huge platform he commissioned while running BP’s business in Angola a few years ago. “I love this stuff.”

Like the pieces of a giant puzzle, the parts showcased here could fit together and build an oil company — and that’s exactly what Mr. Bryant set out to do two years ago after a 30-year career directing energy projects for the likes of Amoco, Unocal and BP. With a team composed largely of retired energy executives, he wants to hunt for oil in the deep waters of the Gulf of Mexico or offshore West Africa, challenging Big Oil in its own backyard.

The American oil patch, once left to languish during an extended period of low oil prices, is on the rebound. Wildcatters like Mr. Bryant are ready to pounce. With oil prices now hovering around $60 a barrel — three times higher than they were throughout the 1990s — the industry is expanding at a pace last seen decades ago.

“The oil industry has changed dramatically in the last 20 years,” Mr. Bryant says. “Barriers to entry have dropped significantly. It doesn’t matter if you’ve been in the business 100 years or 100 days.”

Easily available capital and technology, once the preserve of traditional oil companies, are reordering the business. Investors are lining up to finance energy projects while leaps in computing power, imaging tech-(p. 7)nology and collaborative online networks now allow the smallest entities to compete on an equal footing with the biggest players.

“There’s a lot of money out there looking for opportunities,” said John Schaeffer, the head of the oil and gas unit at GE Energy Financial Services. “It seems like everyone wants to own an oil well now.”

Still, oil exploration remains a costly business fraught with peril. While the odds have improved, success is elusive; three-quarters of all exploration wells come up dry, either because there is no oil or because geologists miss its exact location. All of which means that Mr. Bryant’s start-up, Cobalt International Energy, which plans to begin drilling next year, faces formidable hurdles.

“There’s no sugar-coating this — at the end of the day, it’s a high risk venture,” Mr. Bryant says. “Financially, we’re definitely wildcatting. It’s either all or nothing.”

 

For the full story, see: 

JAD MOUAWADA.  "Wildcatter Pounces; Oil Riches Lure the Entrepreneurs."  The New York Times, Section 3  (Sun., May 20, 2007):  1 & 7.

 

 BryantJosephOilWildcatter.jpg   Wildcatter entrepreneur "Joseph H. Bryant started Cobalt."  Source of caption and photo:  online version of the NYT article cited above.

 

August 3, 2007

Beebe's "Colleagues Reacted Coolly"

 

    Photos of strange deep sea creatures.  Source of photos:  online version of the NYT article cited below.

 

When, more than 70 years ago, William Beebe became the first scientist to descend into the abyss, he described a world of twinkling lights, silvery eels, throbbing jellyfish, living strings as “lovely as the finest lace” and lanky monsters with needlelike teeth.

“It was stranger than any imagination could have conceived,” he wrote in “Half Mile Down” (Harcourt Brace, 1934). “I would focus on some one creature and just as its outlines began to be distinct on my retina, some brilliant, animated comet or constellation would rush across the small arc of my submarine heaven and every sense would be distracted, and my eyes would involuntarily shift to this new wonder.”

Beebe sketched some of the creatures, because no camera of the day was able to withstand the rigors of the deep and record the nuances of this cornucopia of astonishments.

Colleagues reacted coolly. Some accused Beebe of exaggeration. One reviewer suggested that his heavy breathing had fogged the window of the submarine vessel, distorting the undersea views.

Today, the revolution in lights, cameras, electronics and digital photography is revealing a world that is even stranger than the one that Beebe struggled to describe.

The images arrayed here come from “The Deep: The Extraordinary Creatures of the Abyss” (University of Chicago Press, 2007), by Claire Nouvian, a French journalist and film director.

. . .

Beebe, who ran the tropical research department at the New York Zoological Society, surely had intimations of what lay beyond the oceanic door he had opened. “The Deep” brings much of that dark landscape to light, even while noting that a vast majority of the planet’s largest habitat remains unexamined, awaiting a new generation of explorers. 

 

For the full story, see: 

WILLIAM J. BROAD.  "Mysteries to Behold in the Dark Down Deep: Seadevils and Species Unknown."  The New York Times  (Tues.,  May 22, 2007):  D3.

(Note:  ellipsis added.)

 

    "A Ping-Pong tree sponge."  Source of caption and photo:  online version of the NYT article cited above.

 

July 29, 2007

A Public Choice Theory of "Taxonomic Inflation"

 

The excerpt below is from a WSJ summary of an article that appeared in The Economist on May 19, 2007.

 

Scientists have taken to upgrading animals once thought to be subspecies into full-fledged species, in what the Economist says is an overzealous attempt to boost conservation of seemingly rare animals.

Sometimes, the reclassification of animals into their own species category is warranted, as new research reveals once-obscured markers that differentiate certain beasts. But lately, the weekly says, primatologists have been suffering from "taxonomic inflation."

. . .

. . .   One reason is that by fragmenting animal groups, the number of rare species increases, boosting animal-conservation claims.  At the same time, having a greater number of species boosts the chances that a habitat can pursue a legal designation as a protected area.

 

For the full summary, see: 

"Informed Reader; NATURE; Species Inflation May Infect Over-Eager Conservationists."  The Wall Street Journal  (Sat., May 19, 2007):  A6.

(Note:  ellipsis added.)

 

July 17, 2007

Nonprofits Often Fund Risky, but Useful, Research that is Shunned by Government

 

The following excerpt from a summary of a May 17th Nature article, has a message that complements what I found in a paper published a couple of years ago (see the reference at the bottom of this entry).

 

Do charities like the Bill & Melinda Gates Foundation produce better medical research than institutions supported by the government?

. . .

. . . , some scientists believe philanthropies make better use of that $5 billion than corporations or governments, says Nature's Meredith Wadman. Many researchers have stories about nonprofits who rescued risky but useful projects that had been shunned by government-backed institutions. Charities can make decisions more quickly and can take bigger risks. Philanthropists also tend to closely monitor their investments and want the satisfaction of a mission accomplished.

 

For the full summary, see: 

"Informed Reader; PHILANTHROPY; Do Charities Outdo Research By Federal-Backed Agencies?"  The Wall Street Journal  (May 18, 2007):  B6. 

(Note:  ellipses added.)

The reference to the Nature article is: 

Meredith Wadman.  "Biomedical philanthropy: State of the donation."  Nature  447, (May 17, 2007):  248 - 250. 

 

My related paper is:

Diamond, Arthur M., Jr.  "The Relative Success of Private Funders and Government Funders in Funding Important Science."  The European Journal of Law and Economics 21, no. 2 (April 2006): 149-61.

 

May 16, 2007

DNA Scientist-Entrepreneur Venter at Sea

VenterSeaMap.jpg   The projected path of Venter's Sorcerer II ship in collecting sea organisms.  Source of map:  http://scrippsnews.ucsd.edu/Releases/?releaseID=706

 

Craig Venter's private gene-sequencing effort beat the government's effort.  His new research is being funded by a $24.5 million private grant from the Gordon and Betty Moore Foundation.  (For more information beyond the WSJ article excerpted below, see the Scripps Institution of Oceanography press release.)

 

(p. B1)  Marine microbes are among the most abundant life form on the planet and among the most mysterious. Now, results from the first phase of a global expedition are expected to provide a glimpse into this long-hidden world while potentially leading to new drugs and even fighting climate change.

Craig Venter, the brash biologist who helped crack the human genome seven years ago, says he and other scientists have used DNA-analysis techniques to discover millions of new genes and thousands of new proteins in ocean microbes. These microscopic life forms are mainly bacteria and organisms known as archaea.

"Everything we've seen is a surprise," Mr. Venter said in a phone interview from his marine research vessel, Sorcerer II, in the Sea of Cortez. The unexpected variety of microbial DNA he's found overturns earlier notions that the oceans are a homogenous soup of bacteria and other microscopic life. The details are being published today in the Public Library of Science Biology, an Internet-based scientific journal.

A diverse supply of microbial DNA from the oceans could be a rich lode for scientists. Drug companies are hunting for new compounds in sea creatures, especially to attack cancer and neurodegenerative diseases. The new data will also allow researchers to compare the DNA of oceanic bacteria to the genetic code of microorganisms that cause human disease.

"This is the largest DNA sequence ever obtained, and the magnitude of what's being done is entirely unparalleled," said Douglas Bartlett, professor of marine microbiology at the University of California, San Diego, who isn't involved in Dr. Venter's project. Marine microbes "have all kind of metabolic activity. It is expected that [Dr. Venter's team] will discover new pathways for making drugs and treating infectious disease."

 

For the full story, see: 

GAUTAM NAIK.  "Seafaring Scientist Sees Rich Promise In Tiny Organisms."  The Wall Street Journal  (Tues., March 13, 2007):  B1 & B5.

 

   Photo on left shows Venter (on left) on his Socerer II research ship.  Photo on right shows a slide of sea bacteria collected by Venter.  Source of photos:  http://scrippsnews.ucsd.edu/Releases/?releaseID=706

 

May 9, 2007

To the Ultimate Luddites: "Build Coffins, That's All You'll Need"

   Charlton Heston as Robert Neville, the last scientist on earth.  Source of photo:  http://datacore.sciflicks.com/the_omega_man/images/the_omega_man_large_09.jpg

 

In the 1970s, one of my favorite films was "The Omega Man" (1971) starring Charlton Heston as the doctor/scientist who was the last healthy man on earth.  A plague had killed most of humanity, leaving a few in a demented "tertiary" condition.  Heston as "Robert Neville" had developed a vaccine, but only had been able to test it on himself, as the world collapsed.  

Those in the "tertiary" state had been organized by a former broadcast commentator named "Matthias" into the "family" whose goal it was to burn books, and destroy all remnants of science and technology. 

At one point near the end, the family captures Neville, and as the family destroys Neville's paintings, and laboratory, Matthias rants that Neville is the last scientist, the last remnant of the old world, and that all will be well when they have destroyed him.  Then comes one of my favorite exchanges.

 

Matthias: Now we must build.

Robert Neville: Build coffins, that's all you'll need.

 

When I saw the movie again today (3/16/07) for the first time in decades, I was worried that I had built it up in my memory, and that the reality would be way disappointing. 

I was relieved to see that the movie, though not perfect, was still plenty good enough.

 

March 26, 2007

Bush Should Take Lab Coat Off

   Bush in white laboratory coat.  Source of the photo:  online version of the NYT article cited below.

 

Decisions about which new technologies to develop should be left to the market, not the government.  One reason is that markets generally make the more efficient choice.  Another reason is that when technological risks are taken in the market, they are taken with voluntary private money; when risks are taken by the government, they are taken with your money that has been coerced from you through taxation.

With all due respect, President Bush should take the lab coat off. 

  

FRANKLINTON, N.C., Feb. 22 — President Bush put on a white coat and visited a laboratory here Thursday to promote his goals for making alternative fuels from switch grass, woodchips and other plant waste.

After touring the laboratory, which is developing enzymes to make cellulosic ethanol, fuel distilled from plant byproducts, Mr. Bush spoke buoyantly about new technologies that may reduce the nation’s thirst for foreign oil.

 

For the full story, see: 

EDMUND L. ANDREWS.  "Bush Makes a Pitch for Amber Waves of Homegrown Fuel."  The New York Times  (Fri., February 23, 2007):  A16. 

 

January 13, 2007

Feynman on Viking Evidence of No Life on Mars

 

Based on the Viking tests, astronomers concluded that there probably was no life on Mars.  Begley (2006) documents the recent research showing that applying the Viking tests to earth, results in the conclusion that there is no life on earth, either.  Once again, Feynman was way ahead of his time:

  

(p. 204)  We like to sit down and talk about how different things could be from what we expected; take the Viking landers on Mars, for example, we were trying to think how many ways there could be life that they couldn't find with that equipment. 

 

Source: 

Feynman, Richard P. The Pleasure of Finding Things Out: The Best Short Works of Richard P. Feynman. New York: Perseus Books, 1999.

(Note:  italics in original.)

 

The reference on the Begley article:

Begley, Sharon. "Science Journal; Scientists Revisit Data on Mars with Minds More Open to 'Life'." The Wall Street Journal  (Fri., October 27, 2006):  B1.

 

January 8, 2007

"Drawing the Best Minds into a Whirlpool of Mathematical Solipsism"

TroubleWithPhysicsBK.gif   Source of book image:  http://www.houghtonmifflinbooks.com/catalog/titledetail.cfm?titleNumber=689539

 

Physicists rightly feel uneasy about descriptions of the physical world that divide it into discrete clusters of equations and axioms, each cluster explaining one part of existence but not another.  Better would be finding a Theory of Everything capable of conjoining, in a few equations, planet-pulling gravitation and the microcosmic weirdness that goes on in the quantum world of atoms and particles.  Physicists would like to stitch time and space together as well.

Einstein tried and failed.  In recent years, "string theory" has been the favored means of attempting to tie everything together, but it has unraveled into mathematical frippery, positing ever more intricate elaborations extending into anywhere from 10 to 26 dimensions, some arising from themselves, some hidden in ways so baroquely scrolled that you can get a migraine just thinking about thinking about them.  Little wonder that, as an experimental science, string theory seems to have nowhere to go.

That is the problem that Lee Smolin identifies in "The Trouble With Physics."  He laments a kind of sociological imperative drawing the best minds into a whirlpool of mathematical solipsism.

 

For the full review, see:

RUSSELL SEITZ.  "BOOKS; Untangling the Knots in String Theory."  The Wall Street Journal  (Sat., December 2, 2006):  P9.

 

The reference to the book under review, is: 

Lee Smolin.  The Trouble With Physics: The Rise of String Theory, the Fall of a Science, and What Comes Next.  Houghton Mifflin, 2006.  (392 pages, $26)

 

December 30, 2006

Feynman: Nothing in Biology Requires Us to Die

   Source of book image: http://stochastix.wordpress.com/files/2006/08/the-pleasure-of-finding-things-out.gif

 

(p. 100)  It is one of the most remarkable things that in all of the biological sciences there is no clue as to the necessity of death.  If you say we want to make perpetual motion, we have discovered enough laws as we studied physics to see that it is either absolutely impossible or else the laws are wrong.  But there is nothing in biology yet found that indicates the inevitability of death.  This suggests to me that it is not at all inevitable, and that it is only a matter of time before the biologists discover what it is that is causing us the trouble and that that terrible universal disease or temporariness of the human's body will be cured.   

 

Source: 

Feynman, Richard P.  The Pleasure of Finding Things Out: The Best Short Works of Richard P. Feynman.  New York:  Perseus Books, 1999.

 

December 24, 2006

Publishing Pretty Papers Full of Clever Mathematical Tricks

  Source of book image:  http://images.amazon.com/images/P/0738203491.01.LZZZZZZZ.jpg

 

In his elegant and thoughtful foreward, physicist, futurist, and guru Freeman Dyson writes:

(p. viii)  Before I met Feynman, I had published a number of mathematical papers, full of clever tricks but totally lacking in im-(p. ix)portance.  When I met Feynman, I knew at once that I had entered another world.  He was not interested in publishing pretty papers.  He was struggling, more intensely than I had ever seen anyone struggle, to understand the workings of nature by rebuilding physics from the bottom up.   

 

The reference to the book, is:

Feynman, Richard P. The Pleasure of Finding Things Out: The Best Short Works of Richard P. Feynman. New York: Perseus Books, 1999.

December 19, 2006

Feynman: What Biology Needs is Not More Math, But to See Better at the Atomic Level

A very bright, and very mathematically competent, fellow, grants that math is not the source of all knowledge.  So is economics more like physics, or more like biology? 

 

(p. 124)  We have friends in other fields--in biology, for instance.  We physicists often look at them and say, "You know the reason you fellows are making so little progress?"  (Actually I don't know any field where they are making more rapid progress than they are in biology today.)  "You should use more mathematics, like we do."  They could answer us--but they're so polite, so I'll answer for them:  "What you should do in order for us to make more rapid progress is to make the electron microscope 100 times better."

What are the most central and fundamental problems of biology today?  They are questions like:  What is the sequence of bases in the DNA?  What happens when you have a mutation?  How is the base order in the DNA connected to the order of amino acids in the protein?  What is the structure of the RNA:  is it a single-chain or double-chain, and how is it related in its order of bases to the DNA?  What is (p. 125) the organization of the microsomes?  How are proteins synthesized?  Where does the RNA go?  How does it sit?  Where do the proteins sit?  Where do the amino acids go in?  In photosynthesis, where is the chlorophyll; how is it arranged; where are the carotenoids involved in this thing?  What is the system of the conversion of light into chemical energy?

It is very easy to answer many of these fundamental biological questions; you just look at the thing!  You will see the order of bases in the chain; you will see the structure of the microsome.  Unfortunately, the present microscope sees at a scale which is just a bit too crude.  Make the microscope one hundred times more powerful, and many problems of biology would be made very much easier.  I exaggerate, of course, but the biologists would surely be very thankful to you--and they would prefer that to the criticism that they should use more mathematics.

 

Source:

Feynman, Richard P.  The Pleasure of Finding Things Out: The Best Short Works of Richard P. Feynman.  New York:  Perseus Books, 1999.

 

September 27, 2006

"Crystal Fire" Gives Insights on Birth of the Transistor

  Source of book image:  http://www.etedeschi.ndirect.co.uk/homecompbiblio.htm

 

Crystal Fire is a well-written book which highlights many important aspects of the birth of computers.  Not a perfect book---I could have done with a few less details about personal information, like who liked to play bridge and poker, and whose mother was a frustrated artist, and the like.

On the good side, they note how transistors were originally designed to replace vacuum tubes.  The eventual main applications, as memory and processor chips in computers, only came later.  (Another application of Fubini's Law.)

They have a nice discussion of how American science was applied, versus the pure theory of the Germans.  (E.g., to the Germans, some key phenomena leading to transistors, were dismissed as "dirt effects" (pp. 74 & 78).)  The whole episode is a good example of the claim (see Terence Kealey) that very good science can come out of 'industrial' labs. 

They also have a good example of serendipity, in the discussion of the strange chunk of silicon with unusual conductivity properties (circa p. 95).  Reading this episode, it occurred to me that one key enabler of serendipitous discoveries is a scientist or engineer who is carrying around a problem, to which the serendipitous discovery is a solution.  Buddhists need not apply---to carry around problems, you need to be dissatisfied--a milder version of what Tom Peters describes as 'innovation coming from pissed-off people'  (see his Re-Imagine!)

 

Citation to the book:

Riordan, Michael, and Lillian Hoddeson.  Crystal Fire: The Birth of the Information Age, Sloan Technology Series: W. W. Norton & Company, 1997.

 

September 3, 2006

"If Ethanol Made Economic Sense, It Wouldn't Need a Subsidy"

 

  Source of graphics:  online version of the World-Herald article cited below.

 

(p. 1D)  LINCOLN - David Pimentel, a Cornell University researcher, has been criticized repeatedly since he questioned the energy value of ethanol in 1980.

In a government-funded report, he suggested that ethanol provides less energy than is used to produce it.  Even though that report has been disputed and rejected by other analysts, Pimentel has not backed down.

He said last week that rural developers, farmers and investors will rue the day they put their money, hopes and dreams into the corn-based alternative fuel.

"It is too bad," he said in an interview, "because it would be a tremendous asset to agriculture if this were a true winner."

Pimentel is among the public critics who raise red flags as momentum gathers for dramatic increases in production, especially in the nation's top two ethanol-producing states:  Iowa and Nebraska.

While Pimentel is perhaps the expert most often quoted - in part because he presented his analysis more than 25 years ago - others also raise questions about the energy value of ethanol and its economic benefits and environmental effects.

Ethanol backers defend the fuel as a viable way to help stabilize the nation's fuel supply.  But they haven't convinced Jerry Taylor, an energy policy specialist for the Cato Institute, a conservative think tank in Washington, D.C.

"If ethanol made economic sense, it wouldn't need a subsidy," Taylor said.

 

For the full story, see:

BILL HORD.  "High-octane Clash."  Omaha World-Herald  (Sunday, August 6, 2006):  1D-2D.

 

  Source of graphics:  online version of the World-Herald article cited above.

 

August 24, 2006

"Financial Incentives Can Change the Way Medicine is Practiced"


        An angioplasty being performed in Eyria, Ohio.  Source of photo:  online version of the NYT article cited below.

 

Medicare patients in Elyria receive angioplasties at a rate nearly four times the national average . . .

. . .

. . . some outside experts say they are concerned that Elyria is an example, albeit an extreme one, of how medical decisions in this country can be influenced by financial incentives and professional training more than by solid evidence of what works best for a particular patient.

“People are rewarded for erring on the side of an aggressive, highly expensive intervention,” said Dr. Elliott S. Fisher, a researcher at Dartmouth Medical School, which analyzed Medicare data and found Elyria to be an outlier.

Medicare pays Elyria’s community hospital, EMH Regional Medical Center, about $11,000 for an angioplasty involving use of a drug-coated stent.

The cardiologist might be paid an additional $800 for the work.  That is well above the fees for seeing patients in the office.  And with the North Ohio doctors performing thousands of angioplasties a year — about 3,400 in 2004, for example — the dollars can quickly add up.

Some medical experts say Elyria’s high rate of angioplasties — three times the rate of Cleveland, just 30 miles away — raises the question of whether some patients may be getting procedures they do not need or whether some could have been treated just as effectively and at lower cost and less risk through heart drugs that may cost only several hundred dollars a year.

. . .

Experts know that changing the financial incentives can change the way medicine is practiced.

For example, Kaiser Permanente, the big health system that employs its own doctors, says its patients in Ohio, including some in Elyria, are slightly less likely than the national average to undergo the type of cardiac procedures the North Ohio Heart Center doctors perform so prolifically.

Kaiser’s cardiologists, who work on salary instead of being paid by the procedure, typically treat patients in that region at the Cleveland Clinic, where they have hospital privileges.  And they follow established protocols about when a patient should undergo an angioplasty, when drugs might suffice and when bypass surgery might be the best resort.

“It’s not just individual doctors making up their minds,” explained Dr. Ronald L. Copeland, the executive medical director for Kaiser’s medical group in Ohio.  With no financial reason to perform expensive procedures, the Kaiser doctors frequently choose to manage the patients’ heart disease with drugs only.  “Our doctors have no disincentive to do that,” Dr. Copeland said.

. . .

For many cardiologists, the natural tendency when they see a patient with heart disease is to perform a procedure to try to clear arterial blockages.  And patients, cardiologists say, tend to rely on their doctors’ judgment.

“It’s sort of like, you go to a barber and ask if you need a haircut,” said Dr. David D. Waters, chief of cardiology at San Francisco General Hospital, who is currently studying the effectiveness of different kinds of treatment for heart disease.  “He’s likely to say you do.”

. . .

Experts say it can be difficult to detect cases in which doctors cross a medical line and are clearly performing unnecessary treatments.

“A lot of decisions are discretionary,” said Dr. Harlan M. Krumholz, a cardiologist and professor at Yale.

“It’s about where the thermostat is set,” he said, arguing that doctors in a particular geographic area tend to be unaware if the way they are treating their patients is markedly different from the practices of their peers in other areas.

Traditional measures of medical quality are not set up to detect whether patients are being treated too much, he said, unlike the kinds of safeguards that prompt credit card companies to call their customers to discuss unusual spending activity.  “Right now there are no ‘smart’ systems in place,” Dr. Krumholz said.

In the absence of any real monitoring or oversight, doctors in most places, including Elyria, have few incentives not to favor the treatments that provide them the most reimbursement.  Dr. Waters, the San Francisco cardiologist, said that the way physicians are typically paid — more money for more procedures — results in too many decisions to give a patient a stent.

“You can’t be paying people large sums of money to do things without checks and balances,” he said.

 

For the full story, see:

REED ABELSON.  "In Ohio City, a Heart Procedure Is Off the Charts; SIDE EFFECTS; A Stent Epidemic."  The New York Times  (Fri., August 18, 2006):  A1 & C4.

 

Source of graphic:    online version of the NYT article cited above.

August 2, 2006

Life Has Improved; And Can Continue to Improve

 Source of graphic:  online version of the NYT article cited below. 

 

(p. 1)  New research from around the world has begun to reveal a picture of humans today that is so different from what it was in the past that scientists say they are startled.  Over the past 100 years, says one researcher, Robert W. Fogel of the University of Chicago, humans in the industrialized world have undergone “a form of evolution that is unique not only to humankind, but unique among the 7,000 or so generations of humans who have ever inhabited the earth.”

. . .

(p. 19)  . . .  stressful occupations added to the burden on the body.

People would work until they died or were so disabled that they could not continue, Dr. Fogel said. “In 1890, nearly everyone died on the job, and if they lived long enough not to die on the job, the average age of retirement was 85,” he said. Now the average age is 62.

A century ago, most people were farmers, laborers or artisans who were exposed constantly to dust and fumes, Dr. Costa said. “I think there is just this long-term scarring.”

 

For the full story, see:

Health1860s1994.gif Source of graphic:  online version of the NYT article cited above. 

HealthCivilWarAndNow.gif EscapeFromHungerAndPrematureDeath1700-2100BK.jpg  Source of graphic:  online version of the NYT article cited above.  Source of book image:  http://www.cambridge.org/us/catalogue/catalogue.asp?isbn=0521808782

 

Fogel's book is a primary academic source for much of what is interesting in the New York Times article.  Fogel predicts that if we don't screw things up, half of today's college students will live to be 100.  He shows that academics in the past have consistently and significantly underestimated the maximum lifespans that would be attainable in the future.

The full reference for the Fogel book is:

Fogel, Robert William. The Escape from Hunger and Premature Death, 1700-2100, Cambridge Studies in Population, Economy and Society in Past Time. Cambridge, UK: Cambridge University Press, 2004.